Complete loss of ischaemic preconditioning-induced cardioprotection in mice with partial deficiency of HIF-1a

نویسندگان

  • Zheqing Cai
  • Hua Zhong
  • Marta Bosch-Marce
  • Karen Fox-Talbot
  • Lei Wang
  • Chiming Wei
  • Michael A. Trush
  • Gregg L. Semenza
چکیده

Vascular Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; McKusick-Nathans Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, Suite 671, 733 North Broadway, Baltimore, MD 21205, USA; Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Departments of Pediatrics, Oncology, and Radiation Oncology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; and Department of Environmental Health Sciences, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, MD 21205, USA

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HIF-1α and paradoxical phenomena in cardioprotection.

Ischaemic preconditioning, i.e. one or several brief cycles of myocardial ischaemia/reperfusion preceding a more sustained period of myocardial ischaemia with subsequent reperfusion, does not increase the resulting size of myocardial infarction but paradoxically decreases it. Over the past 25 years, ischaemic preconditioning has become the key paradigm of endogenous cardioprotection, and numero...

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Complete loss of ischaemic preconditioning-induced cardioprotection in mice with partial deficiency of HIF-1 alpha.

AIMS We investigated whether hypoxia-inducible factor 1 alpha (HIF-1 alpha) plays a role in the acute phase of ischaemic preconditioning (IPC). METHODS AND RESULTS Hearts from wild-type (WT) mice and mice heterozygous for a null allele at the locus encoding HIF-1 alpha (HET) were subjected to IPC (10-min ischaemia/5 min reperfusion, or two cycles of 5 min ischaemia/5 min reperfusion), followe...

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Hypoxia-inducible factor-1 is central to cardioprotection: a new paradigm for ischemic preconditioning.

BACKGROUND Ischemic preconditioning provides strong cardioprotection from ischemia, but its molecular mechanisms remain unknown. Convincing evidence confirms a central role of hypoxia-inducible factor (HIF)-1 in mammalian oxygen homeostasis. Thus, we pursued HIF-1 as a central component of cardioprotection by ischemic preconditioning. METHODS AND RESULTS Murine studies of in situ precondition...

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Exploring the role and inter-relationship among nitric oxide, opioids, and KATP channels in the signaling pathway underlying remote ischemic preconditioning induced cardioprotection in rats

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تاریخ انتشار 2007